Aside from excessive meddling, the other big complaint against regulation is that it hurts the economy. No one really knows by how much, but "there is ample evidence that regulation has expanded and that this expansion has limited economic growth," as Ted Gayer and Philip Wallach of the Brookings Institution recently wrote. One study estimates that regulation has shaved 0.8% off the U.S. annual growth rate which — if confirmed by other studies — would be huge.
Some possible approaches to improving matters:
Confirming Gorsuch to the Supreme Court could well help: "Gorsuch’s Collision Course With the Administrative State".